Optimizations that are easier to implement and that have a higher return on investment are better than the alternative optimizations. Furthermore, most popular optimizations do not deliver high returns on investment.
Ramit Sethi outlines (in eye-catching ways) how one can figure out which optimizations are worth your effort. Mostly, his advice hinges on differentiating yourself from everyone else:
As you can see, many Big Wins are actually easily within reach—if you choose the right targets and differentiate yourself from others. While you'll have a few areas of life where you'll have to go up against formidable competition, many other areas of life are wide open.